The Effect Of Aloe Vera Gel On Liver Enzymes Of Albino Rat
– The Effect Of Aloe Vera Gel On Liver Enzymes Of Albino Rat –
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ABSTRACT
The study was designed to investigate the effects of administration of Aloe vera gel extract on liver enzmes on Albino rats. Twenty four male Albino rats weighing 180-200 were divided into four groups of six rats per group were used in the study.
Group I which served as the control received rat food and water while those in groups II, III and IV received Aloe vera gel (100, 200 and 300mg/kg), respectively, for three weeks.
The animals were sacrificed, and serum enzymes were measured using standard methods. Serum ALT concentration was nonsignificantly reduced (P>0.05) in group 2 (47.80±7.33 IU/L), compared with group 1 (54.50±3.89 IU/L).
While in group 3 (63.50±3.78 IU/L) and 4 (71.17±2.40 IU/L) it was significantly increased (P<0.05) when compared with group 1. Serum ALT concentration was significantly higher (P<0.05) in group 3 compared with group 2.
It was also significantly higher in group 4 compared with group 3. Serum AST concentration was non significantly lower (P<0.05) in group 2 (54.17±4.40 IU/L) when compared with control (56.67±3.08 IU/L).
Serum AST concentration was significantly higher (P<0.05) in group 3 (67.67±3.20 IU/L) and 4 (75.50±2.35 IU/L) when compared with control (Group 1).
It was also significantly (P<0.05) higher in group 3 compared with group 1, and group 4 compared with group 3. Serum ALP concentration was nonsignificantly lower (P>0.05) in group 2, 3 and 4 (77.17±4.02 IU/L, 75.17±5.71 IU/L and 73.67±4.63 IU/L respectively).
When compared with control (81.67±4.84 IU/L). Serum ALP concentration was non significantly lower (P>0.05) in group 3 when compared with group 2, and in group 4 when compared with group 3. In conclusion, Alovera gel has hepatoprotective and hepatotoxic effect.
INTRODUCTION
Background of Study
Liver is one of the largest and vital organs of human body and is vulnerable for tissue insult continuously. Liver regulates various important metabolic functions, the distortion of which causes hepatic damage (Wolf, 2016). Liver disease is still a worldwide health problem. Drug-induced hepatotoxicity is one of the major concerns which limit the therapy and drug use. About 2% of all causes of jaundice in hospitalized patients are drug induced.
Approximately quarters of cases of fulminant hepatic failure are thought to be drug related. More than 900 drugs have been implicated in causing liver injury and it is the most common reason for a drug to be withdrawn from the market (Friedman et al., 2013).
Conventional or synthetic drugs used in the treatment of liver diseases are inadequate and sometimes can have serious side effects. This is one of the reasons for many people in the world including those in developed countries, turning to complementary and alternative medicine. Many traditional remedies employ herbal drugs for the treatment of liver ailments (Dhuley & Naik, 2007; Venkateswaran et al., 2011; Latha et al., 2009 and Mitra & Seshadri, 2000).
Aloe vera has been used for many centuries for its curative and therapeutic properties. The use of Aloe vera gel has been promoted for the management of many disorders. Aloe vera is a succulent perennial plant belonging to family Liliaceae, having over 350 species (Rodriguez et al., 2010).
Aloe vera gel which is visible on slicing the Aloe leaf has been reported to be beneficial in T1DM (Nna et al., 2014; and Nna et al., 2013), atherosclerosis (Akpan et al., 2014) and wound healing (Davis, 2009). Aloe vera latex which is obtained from the inner part of the skin of the leaves has been reported to contain anthraquinones and possess laxative effect.
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